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Published on:

11th Aug 2026

GLP-1 Weight Loss: What You Need to Know Before, During & After the Shot | Ashley Koff, RD

What if the goal is not to become smaller, but to help your body work better? In this episode of Doing Divorce Different, Lesa Koski talks with registered dietitian and weight-health expert Ashley Koff, RD, author of Your Best Shot: The Personalized System for Optimal Weight Health—GLP-1 Shot or Not.

Ashley reframes GLP-1 weight loss by explaining why weight is a signal—not a moral judgment—and why total weight can include bone, muscle, fat, and water. She shares how naturally occurring GLP-1 and related hormones are connected with appetite, satiety, blood sugar, digestion, and other aspects of metabolic health.

You will hear a nuanced conversation about when GLP-1 medication may be one helpful tool, why it is never the entire plan, and what to consider if you experience side effects or prefer a non-medication approach. Ashley also discusses food noise, gut health, hydration, nourishment, strength, sleep, and the often-missed role of rest and recovery.

For anyone navigating divorce, menopause, illness, or another major life transition, this episode offers a more compassionate way to approach GLP-1 weight loss and overall well-being. Instead of chasing a number on the scale, Ashley encourages listeners to protect muscle, bone, energy, and the resources needed to live their purpose.

If you are curious about GLP-1 weight loss, struggling with food noise, or wondering why a popular plan has not worked for your body, listen before making your next move. Save this episode, share it with a friend, and bring your questions to a qualified member of your health-care team.

This episode is educational and is not medical advice. Consult qualified health professionals before starting, stopping, or changing medication, supplements, nutrition, or exercise.

Timestamps (in parentheses):

(00:00) Introduction to weight health with Ashley Koff, RD

(07:00) Why weight is a signal—not a judgment

(10:00) GLP-1 medications are a tool, not a magic solution

(12:40) GLP-1, GIP, muscle, and bone-health nuance

(17:05) What everyone needs—with a GLP-1 medication or without one

(21:30) How to evaluate whether medication may fit your needs

(30:15) Your Best Shot and the foundations of digestion and hydration

(34:50) Why drinking more water is not the whole hydration story

(38:30) Food noise and ways to support the body without medication

(43:35) Why “weight loss” may include losses you do not want

(49:15) Rest, recovery, and caring for yourself during divorce

(52:10) Giving yourself the best shot at your next chapter

(54:05) Closing thoughts and where to learn more

Timestamp note: These timestamps are based on the supplied transcript and should be checked against the final edited audio or video before publishing.

Key Takeaways:

  • Weight health includes bone, muscle, fat, water, energy, digestion, and other signals—not only the number on the scale.
  • GLP-1 medications may be useful for some people, but they do not replace individualized nutrition, hydration, movement, sleep, monitoring, and recovery.
  • “Weight loss” can include unwanted muscle, bone, water, hair, and energy loss; a better plan defines the specific outcome being pursued.
  • Food noise and medication side effects deserve personalized assessment rather than shame, guesswork, or one-size-fits-all advice.
  • During divorce or another demanding transition, rest and recovery are legitimate parts of caring for your health.

Guest Bio:

Ashley Koff, RD, is the USA Today bestselling author of Your Best Shot (HarperOne), founder of The Better Nutrition Program (BNP), and a pioneering voice behind the emerging weight health movement. A practitioner and thought-leader with more than 25 years of experience, Ashley has helped redefine how we approach weight, shifting the conversation from weight loss to weight health, a science-based framework focused on metabolic function, hormonal regulation, and sustainable outcomes. Through her work with patients, clinicians, leading brands and companies, and health organizations, Ashley has developed practical systems that translate complex nutrition science into personalized strategies people can actually implement. In Your Best Shot, Ashley introduces the concept of weight-health hormones, GLP-1, GIP, CCK, and PYY, as key regulators of weight health. The book presents the first functional assessment framework for these hormones along with a personalized optimization approach designed to support weight health whether using GLP-1 medications or not (“shot or not”). A trusted expert featured across major media and a sought-after educator for health professionals, Ashley has been recognized as one of CNN’s Top 100 Health Makers and named “Hollywood’s Leading Dietitian” by InStyle. Through her clinical work, educational programs, and writing, Ashley continues to lead a growing movement toward better, not perfect, nutrition that supports long-term metabolic and weight health.

Resource Links:

https://www.instagram.com/ashleykoffapproved/?hl=en, https://www.linkedin.com/in/ashley-koff/, https://substack.com/@ashleykoffrd?r=3fuq67&utm_campaign=profile&utm_medium=profile-page

Affiliate disclosure: Lesa may receive compensation if you make a purchase through an affiliate link, at no additional cost to you.

Tags/Keywords:

GLP-1 weight loss, weight health, Ashley Koff RD, Your Best Shot book, GLP-1 medications, GLP-1 shot or not, gut health, food noise, metabolic health, women’s health, nutrition during divorce, divorce wellness, muscle loss, bone health, strength training, rest and recovery, hydration, semaglutide, tirzepatide, appetite hormones, personalized nutrition, healthy weight management, perimenopause health, menopause nutrition, Doing Divorce Different, Lesa Koski

Transcript
Speaker:

Welcome back, listeners.

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I am so excited.

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I have such a treat today, and this is,

like, such a treat for me, and this is

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the Doing Divorce Different podcast.

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And we talk about being well through hard

transitions, and just in life in general.

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I mean, this really can

be helpful to anyone.

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But I have the lovely Ashley Koff

with me today, and she's a big deal.

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I mean, you really are.

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You're one…

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I mean, I think InStyle Magazine

said you were the top dietician

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for Holly- This is amazing.

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We're gonna talk about

weight health, I think.

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Is that what you call it?

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Weight health.

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Not weight loss, weight health.

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And Ashley, as a woman living life

This is something that we, we all

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deal with, I truly believe, or

family members dele- deal with.

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So Ashley's got a book o- out

called Your B- is it Your Best Shot?

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Correct.

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Is that what?

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Mm-hmm.

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Yeah.

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Yeah, and I know that you

talk about GLP-1s, and you

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talk about not using GLP-1s.

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So we're gonna, like, just dig into

all the good information about being

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healthy, um, and our weight and nutrition.

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So I just- I'm so thankful

that I get to have a big deal

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on and I get to, like, learn.

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I'm gonna be taking notes as you go.

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But welcome, and would you mind

just sharing with the listeners what

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led you to do this amazing work?

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Speaker 2: Well, thank you so much.

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Um, and I love this.

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We're all big deals.

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Like, so let's just be super clear.

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We are an ecosystem.

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Like, there are so many people that I

have met through my work that are so

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important to our lives and everything

that this planet and people need.

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And when we are challenged by our

not having weight health, um, we are

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then not able to fulfill our lives.

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Like, to…

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And- and one of those challenges

is when life throws us a curveball

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or when we create a curveball, and

we're like, "I don't wanna be with

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that person," or, "I'm choosing not

to be with that person," and here.

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So for me, this really goes

back to my eight-year-old self.

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Um, and I was, like, born a badass.

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Like, I was, I just was out there.

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I was, uh, born in the- the Midwest.

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I had two brothers.

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I was the only girl in my family

for, like, generations, but, um, I

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never thought of that as different.

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Like, it was just, like, go.

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Like, you're gonna run,

you're gonna change the world.

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At eight, society was

like, "You have a belly."

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Kids and adults and other

people were like, "You're fat."

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And my doctor was like, "You're no longer

normal," like, on a, on a BMI chart, you

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know, or whatever they were looking at.

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So for me, that was a moment.

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I actually didn't take that moment and

was like, put my head in the sand and

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was like, "Oh, I'm not a badass anymore."

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Like, I'm not, you know, whatever.

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I was like, "Uh-oh, I got a weakness."

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Like, this superhero's got a kryptonite.

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I gotta get rid of that.

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So I started down the path that society

tees up for all of us, which is diet

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and exercise, and also under feeling

and believing, because what I was

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told was my weight was my problem.

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It was mine to deal with.

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It was my responsibility, and if diet

and exercise didn't work, I was the

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pro- like, I was a failure, right?

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So it was so disempowering.

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There were moments where it worked.

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Like, you know, if I didn't eat or

when I had my tonsils out, like, I lost

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weight, and it was like, "Oh, great."

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Like, "Look at you, size six," you know?

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But all through that time period,

it was these highs and lows

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based on something that, like, I

literally didn't have control over.

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And that, for me, was

like this constant…

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It was almost like I was living two lives.

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'Cause the rest of my life, if I

worked hard at anything, I could

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accomplish what I wanted to accomplish.

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So years later, I-- after dieting

and all this other stuff, I would

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become a dietician because I

thankfully met someone who actually

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told me that my weight was a signal.

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More importantly, he told me that my

weight's components were a signal,

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and that those components were telling

us that my body wasn't working the

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way that it was supposed to work.

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And he honed in on, "You've been

taking antibiotics your whole

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life, and then you added birth

control, and then you drank alcohol.

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And like, you did all these things that

disrupted how your gut was functioning.

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And at times, you got really

stressed about it, or you stressed

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your body out by over-exercising

and under-resourcing, et cetera."

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All of that meant that

it really didn't matter.

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He said to me, "It literally isn't

what you eat or what you're not eating.

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It's that your digestion

isn't working right.

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It doesn't have-- Your body doesn't

have what it needs to work better."

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That's why I became a dietician.

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That's why I turned around and was

like, "Holy moly, it wasn't me."

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Like, right?

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And that's the moment I want

you all to have right now.

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This isn't you.

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This moment right now is, we

have been sold a bill of goods.

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We have been sold a faulty bridge.

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It's a plank.

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Weight loss and focusing on total weight

doesn't get us to where we wanna go.

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We wanna go where our body has what

it needs and, as a result, it works

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the way it's supposed to work.

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And even when it's not working the

way it's supposed to work, you know, a

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disease happens or something happens,

it's res- we've built a resilience, and

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so we can overcome those challenges.

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That's weight health.

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And weight health is where your body's

weight, the parts of your weight,

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your bone, your muscle, and your fat,

and the water content, they tell us.

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They're signals, just like your blood

pressure, your blood sugar, your energy.

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Like, they're signals that tell us things.

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So then in 2004, I met GLP-1 and GIP.

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These are hormones that we make in

the lining of our digestive tract

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that you guys hear about today

as a medication, a GLP-1 agonist,

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or tirzepatide as GLP-1 and GIP.

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But they're actually hormones in our body.

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So it'd be like if you just met

Synthroid today and you were like,

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"Oh my God, Synthroid is this

thing that helps my thyroid run."

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And then you're like, "Wait, no, it's

actually a thyroid hormone," right?

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So we have these hormones.

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Those hormones regulate bone, muscle, fat,

water, blood sugar, appetite, satiety,

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blood flow, blood pressure, inflammation.

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I could keep going on.

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Our body makes weight health hormones.

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So why in the world would the goal be

anything other than to optimize our

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weight health by making sure that these

hormones are working better for us?

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And we can do that by replacing

them with medication, or we

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can do that without medication.

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So that's the whole…

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There you go, my dear.

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Okay.

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And we're going to deal with that

now so that everybody, no matter

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what you're going through in your

life, can learn and understand how

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to optimize your weight health.

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Speaker: I love this.

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I love this.

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And okay, and I wanna hear both.

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I wanna hear about how to do it

with- without using the medications.

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Speaker 2: Yes.

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Speaker: And then I've, I know a

lot of people, I have a lot of close

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friends who are on the medication.

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Yeah.

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They've had great results.

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And, and I wanna find out from

you, are there any downsides?

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I've had people on the podcast that

have said, "Oh, maybe it's kinda messing

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with your bone density a little bit."

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Speaker 2: Yeah.

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Speaker: Um, you know, I don't- And

this is my humble opinion, I don't

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know really a lot about it, but I kinda

think it's not like the magic pill.

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You still have to be healthy

overall and, and do your lifting

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and your walking and all that.

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But you, you get to start where you want.

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Do you wanna talk about the GLP?

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Let's

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Speaker 2: start here.

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All right.

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Let's start with any

medication is not a magic pill.

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All right?

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Any diet plan, any program, like so eating

100 grams of protein or what, you know,

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whatever it is, there's no one tool or

pill that is the solution to our health.

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The other part about this is

we have so much weight bias.

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Remember I told you that the weight…

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Okay, so the wellness

industry is like $2 trillion.

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The weight indust- I mean, we're like

in the billions of dollars in, in

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when, you know, when we look at this.

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Their thesis is, uh, in order to make

money, they have to tell you that you're

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the problem, and that with their tool

you will be able to achieve what it is

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you want to achieve, and that's flawed.

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What I'm here to tell you is your

body not working the way that it's

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supposed to, we have to decode that

and we have to help it work better.

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So when we talk about these

medications, I want us to understand

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that everything that I'm about to

say applies for every medication.

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Just gonna give you an example.

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If you smoke a cigarette every day and it

helps you poop every morning, and then you

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quit smoking and suddenly you don't poop

every morning, that's because you quit

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using the agent that was helping you poop.

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Same thing for coffee or caffeine, and the

same thing for a medication that millions

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and millions of Amer- Americans are on.

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You can choose it.

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It's a proton pump inhibitor which

suppresses stomach acid if our

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acid is too high, or maybe you're

on a statin and you're getting…

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You're lowering your cholesterol there.

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If you use either of those and

you say, "Let me just take that

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and just keep going," you're

actually not gonna be healthier.

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50% of people who have heart attacks

or have heart- and have cardiovascular

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disease have it with normal cholesterol,

and most of that cholesterol normal

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is because they've used a medication.

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So when we use a GLP-1 agonist

medication, we can't come in and say,

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"I take this medication, I lose weight.

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I take this medication,

I fix my blood sugar."

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It is a tool that is part of the solution.

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So that's the first reframe, you

know, that we have to make as

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it relates to the medication.

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The second thing is that your person,

with all due respect, who came on

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and said the medication is a problem

for your bone is actually wrong.

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You, with these, these hormones,

GLP-1, and in particular GIP,

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which we find in tirzepatide.

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So semaglutide is just GLP-1, tirzepatide

is GLP-1 and GIP, and then the new

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retatrutide is GLP-1, GIP, and glucagon.

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GIP, actually we have receptors for it,

which means the hormone goes there and

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activates action on our osteoblasts.

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Those are our bone-building cells.

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So we can actually use tirzepatide to get

more hormone to our bone-building cells.

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Here's what your, what the person w-

uh, could have said more appropriately.

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Number one, if you're using

semaglutide and you're not using

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tirzepatide, you're not getting GIP.

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The second comment is, if you use this

medication at either too high of a

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dose or use it in a manner where it,

it interferes with your body getting

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the nutrient resources that it needs,

so you, you're not taking in an optimal

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amount of, of nutrients, or you use the

medication, and this is where the dose

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is really i- important, this medication

delays our gastric emptying, which

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means it challenges our digestion.

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So if we don't optimize our digestion

well on the medication, so like

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kind of figure out what that means

for you, your body might get the

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nutrients, but they might not get

where they're supposed to go, right?

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So if that, if any of that situation

happens, you could be not giving

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your bones enough of what they

need, or if you're too tired to

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strength train or move or do other

things, we might not get there.

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So in all of these nuggets that you hear

online, social medias, it's why I wrote

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a book on it, there are aspects of this

that are true, but usually the statements

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are made into a mass statement, and

that's where they're false on that part.

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Okay.

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Speaker: I…

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So now let me ask one question.

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Yeah.

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So for those who are on a GLP,

are most of them on the other

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medications that help your bones

too, or are they just on the GLP?

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Speaker 2: So, okay, a GLP-1 agonist

is a class of medic- medications.

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Underneath it, you have semaglutide,

um, tirzepatide, and then coming

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soon, and some people are already

taking it, um, w- is retatrutide,

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but it hasn't been FDA approved.

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We also have a medication

called Fundio or orfoglipron.

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Fundio is the brand name orfoglipron.

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So orfoglipron is a

different kind of medication.

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It's called a small molecule nonpeptide.

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It- any of what I just

said doesn't apply there.

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In the world of retatrutide, semaglutide,

and tirzepatide, only if you're on

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tirzepatide and retatrutide are you

getting the hor- the one hormone

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that, uh, actually there's a receptor

site for it on the osteoblast.

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But, but GLP-1 still has a favorable,

it's a lot more indirect role- can have

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favorable, um, bone building outcomes.

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And we've seen that in the research.

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We've just seen the research also on

people who have lost bone, but also

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they may have been losing bone…

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Like, I was losing bone in my

teens because I was dieting- Mm-hmm

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and, and I wasn't pooping right.

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So it's like there are all

these reasons, you know?

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Right.

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So if you've been dieting, you know…

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So it's like so, you know,

we, we, we're not as…

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We're assigning blame to the medication,

where the blame is really about, you know,

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what that person's body isn't getting

or, or how it's working on that part.

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Speaker: Got you.

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Yeah.

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Thank you.

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Thank you for clarifying that.

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Speaker 2: Yeah.

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Yes.

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So I think what we want, what we wanna

understand is everyone, on or off a

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medication, 'cause even the people

who are using a GLP-1 agonist today,

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they may not be on it forever, right?

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Or they may stay on it

forever at different doses.

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On or off the medication, our job

is still to optimize these hormones,

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because these hormones are a

part of our body's system, right?

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So the example that I would give is

what if you took estrogen, but you

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did all of these things in your…

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You didn't do anything in

your body to build bone, make

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muscle, address vaginal…

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Like, estrogen doesn't just

do all of those things.

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We still have to…

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You know, or thyroid hormone, or you

take a statin medication and you,

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like, and you still eat, like, um, you

know, uh Sundays all day, you know?

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Right.

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Or whatever.

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Like, so we…

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So in this space when we're on the

medication, and what the medication should

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be doing is helping make those choices

more doable for you and your body, right?

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So as an example, if on the medication

I now can lean into eating a better

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amount for my body, I still have

to make sure that what the…

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That might be a quantity conversation.

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Now I still need to make sure that

in that amount I'm getting enough

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protein, fiber, um, magnesium, vitamin

D, like, you know, creatin- like, all

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of these different things, otherwise

my body won't be optimally resourced.

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So what the medication can do

is enable that in the body.

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What the medication cannot do is fix

what's going on in your vagus nerve,

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what's going on in your arteries,

what's going on in your digestion,

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all the things that maybe were making

it so that your, your own hormones

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weren't able to work successfully.

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So my plan, my program, my protocol

is for anyone in that space.

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That's why I wrote this.

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It was like, we're gonna lose the plot

if we turn around and say, "Only an obese

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person should use this medication, and

they should use it for weight loss."

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That is the totally problematic approach.

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What we do for an obese person is the

same thing we do for somebody who has

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three extra pounds of fat on their body

or 10 extra pounds of fat on their body.

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We optimize digestion.

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That includes also hydration.

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We optimize your, what I call your

total nutrition or better nutrition.

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That's how your food and your

supplements together give your body

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an optimal amount of resources.

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Magnesium, like, all of

these other ones, right?

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And then we optimize lifestyle choices.

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So we turn around and we say, "Okay.

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Are you moving your body enough?

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Are you challenging your

muscles often enough?

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But also, are you recovering,

relaxing, sleeping enough?"

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Because someone who's on this medication,

the way the medication works is

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while you're sleeping, it is actually

stimulating your metabolic hormones.

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That is going to worsen your recovery.

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That in- interferes with the

body being in rest and digest.

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So when people are telling me that

they have fatigue, and, and some people

316

:

have really significant fatigue- And

where when the articles, the media,

317

:

and everybody else or, or other experts

or people or non-experts are saying,

318

:

"Oh, it's 'cause you're not eating

enough," it's like, no, it's the

319

:

actual mechanism of the medication.

320

:

It's suppressing your

body's rest and digest.

321

:

So my job is to come in and say,

"Okay, if that's happening, do

322

:

we need you on a lower dose?

323

:

Do we need to change what we do

for you while you're sleeping?

324

:

Like, what could we optimize there

so that we can find that sweet spot

325

:

where the pros of the medication are

what we want, but the considerations

326

:

are not negating the pros," right?

327

:

That's always what we're looking

for in a medication is, how do

328

:

we drive those better outcomes,

you know, i- i- on that part.

329

:

So that's how we can look

at it, medication or not.

330

:

Yeah.

331

:

Speaker: Okay, okay.

332

:

That's so…

333

:

That's helpful.

334

:

So I mean, do you

recommend the medication?

335

:

Is it helpful to…

336

:

Tell me when you rec- when

you would recommend it.

337

:

Speaker 2: Yeah, totally.

338

:

So as a, I call myself

the backwards doctor.

339

:

My nephew came up with that term at

340

:

age four.

341

:

I love it.

342

:

So he's DR.

343

:

Like, he was like, "What?

344

:

My, my, my one aunt is a DR, but

you're an RD," and, you know.

345

:

And I was like, yeah.

346

:

I was like, "So she'll diagnose

your body, you know, she'll tell

347

:

us, and she'll, you know, prescribe.

348

:

But I'm gonna come in, I'm gonna work

backwards, and I'm gonna actually say,

349

:

'Here's what your body's signaling.

350

:

Here's what your choices are.

351

:

What do we need to…

352

:

How can we fix those so that

we get optimal results?'"

353

:

So as a backwards DR, I'm not prescribing

the medication, but I often am ha- the

354

:

one who's having the conversation about,

is this the better tool for you today?

355

:

Some of the things to evaluate on

that part that don't get talked about,

356

:

so I think this is really important.

357

:

Number one, we wanna do a

different kind of assessment.

358

:

We want to assess how your body is

functioning today to make sure that

359

:

we understand if and when you start

the medication, we know how to get

360

:

ahead of things that could create side

effects that would be intolerable.

361

:

So if you're somebody like millions

and millions of Americans who have

362

:

existing digestive issues, maybe you

take medications for it, maybe you, you

363

:

know, drink coffee or take magnesium for

it, you know, whatever on that part, we

364

:

wanna know that, and then that's gonna

help us personalize what medication

365

:

we choose and also what the doses are.

366

:

The second one that's so

important is budgeting.

367

:

So I want you to budget three types

of resources, and for those of you

368

:

who are navigating divorce, this is

such an important thing to consider.

369

:

Yes, everybody talks about

financial resources, and I get it.

370

:

You know, we're dealing with

lawyers or custody, like, all

371

:

sorts of different things, right?

372

:

Finances are gonna be key, but

also your time and also your hope.

373

:

Right?

374

:

Your emotions in here, and how quickly

or what kind of emotional bandwidth

375

:

you have available is going to be

very important for us to talk about.

376

:

So I, I do a budgeting conversation, and

the reason is, is that I really think

377

:

that most people for this particular

therapy should consider a year.

378

:

A year is probably the shortest time

period in which you might start on

379

:

the medication, assuming positive,

like that it's positive, that we

380

:

can manage anything, and assuming

nothing else happens in your life

381

:

where we have to come off of it,

um, for, you know, other reasons.

382

:

We're going to want you on it for a

period of time at the pace that you

383

:

and your body can handle, that we're…

384

:

And then we're gonna learn from what it…

385

:

And learn to optimize and use this tool.

386

:

And should we decide either you have

to come off of it, maybe finances,

387

:

access, or that you, we, we get to a

goal, or that for some other reason

388

:

we're choosing to come off of it, maybe

you've decided to now get pregnant, you

389

:

know, whatever on that part, we have

enough time to help you come off of it,

390

:

it, where your body responds favorably,

where we set you up for success and

391

:

we understand what that looks like.

392

:

So that's not shorter than a year,

and in that time period, that

393

:

means finances for access to the

medication, access to someone like me.

394

:

I definitely have, I have my book, and

you get access to our community, so

395

:

there's a lot that's free in there.

396

:

You could even borrow it from the library.

397

:

But oftentimes to personalize, we

need at least one session or maybe

398

:

one session a quarter, you know,

kind of as you're, as you're going

399

:

through And then also the resources

associated with things like maybe you

400

:

need time with a therapist in here.

401

:

Maybe as you're shrinking your fat

cells, if that's an intended goal,

402

:

your op- your, um, some of what's

coming out of those fat cells are

403

:

physical toxins, so we need those to

be eliminated, but emotional toxins.

404

:

A lot of us gained weight in relationships

where we were maybe protecting

405

:

ourselves or not dealing with certain

things or putting other people first

406

:

and not putting ourselves first or

other, you know, a lot of things.

407

:

Or maybe the ra- the reasons for

which this relationship are ending

408

:

have caused us, you know, to gain

weight, you know, in that part.

409

:

When we are unpacking those, we can't

unpack those too quickly, right?

410

:

And we also often need support,

you know, i- in terms of it.

411

:

So I have that budgeting conversation,

and then we come in on the medication and

412

:

we say, "Okay, now if you're on it…"

413

:

Now we're, we might start, and

we choose the medication really

414

:

based on two different things.

415

:

One, can you do and are you

safe to do an injection?

416

:

If you're not safe to do an

injection, we're gonna look at an

417

:

oral, and that's gonna have some

different, you know, conversations.

418

:

That's typically a one day do- once

a day versus a seven day, and that's,

419

:

that'll have outcome im- implications.

420

:

And then if you can do an injection,

we'll look at which type of the

421

:

medication would be better for you,

and something like bone health.

422

:

And I'll give you an example.

423

:

I have a lot of, um, women who are

perimenopause or menopause or even just

424

:

before, um, and have, based on their

history of cancer or other factors, have

425

:

decided that they cannot or, or will

not have, uh, be able to use estrogen,

426

:

right, as a hormone replacement therapy.

427

:

Estrogen's really important for our bones.

428

:

So side by side in our gut

lining, we make our weight health

429

:

hormones and our sex hormones.

430

:

There are receptor sites for estrogen

and there's receptor sites for GLP-1.

431

:

Well, in those osteoblasts you

have receptor sites for GIP and

432

:

you have estrogen receptors.

433

:

So if we can…

434

:

One thing that we might decide to do

is use tirzepatide for someone who

435

:

maybe couldn't use estrogen, right?

436

:

So there are all these considerations, you

know, that go, that go into the selection.

437

:

And then we, once you're on it,

we're consistently evaluating right

438

:

dose and sort of the, you know, is

staying on it the right thing for

439

:

you, you know, based on outcomes,

you know, and, and other things.

440

:

Um, one of those pieces, and again,

why, you know, often you wanna be

441

:

involved and have a conversation

with someone like myself is maybe

442

:

you're on other medications.

443

:

So one of my favorite parts of this

medication is that I often help

444

:

people come off of other medications.

445

:

I have people who are on like three

different medications for their blood

446

:

sugar, and they come, they're able to

come off of those once we actually are

447

:

helping their medic- their body use the,

you know, the insulin and have the blood

448

:

sugar response and other things based on

their GLP-1 and their GIP working better.

449

:

So there's so many considerations.

450

:

I don't think you knew that there

was, like, a whole, like, 27 list

451

:

here, you know, when you asked

the question, but that's how we

452

:

go through the process, right?

453

:

Right.

454

:

It's not a fill out this five-question

form online and see if somebody

455

:

says to you, you qualify, and

now get the medication sent to

456

:

Speaker: you.

457

:

Yeah, it's, it's not an easy answer.

458

:

No.

459

:

And, and I'm thinking here and I'm

sitting here and I'm like, okay, for

460

:

listeners, I think the first thing…

461

:

A- and for myself, the first

thing is I'm gonna read the book.

462

:

Speaker 2: Yeah.

463

:

Yep.

464

:

Speaker: Because I'm assuming

there you're gonna talk about

465

:

what I can do without the shot.

466

:

Speaker 2: Yeah, everything.

467

:

Right.

468

:

With or without the shot.

469

:

Speaker: With or without.

470

:

Speaker 2: Yeah.

471

:

Yeah, yeah, absolutely.

472

:

And I think one of those pieces

is it is not optional for us to

473

:

optimize our digestion, and we never

get to achieve optimal digestion.

474

:

Our digestion is always changing.

475

:

One of the biggest mistakes that

we've made in the world of nutrition

476

:

is we've taught people that food is

healthy or not healthy for them, right?

477

:

There are even brands, like, called

Healthy Choice or the, you know, this is

478

:

healthy, or there are logos on something,

this is healthy, this is healthy.

479

:

Your body doesn't decide if something is

healthy until what you take in, food or

480

:

supplement, gets where it's supposed to

go, when it's needed, and can be used.

481

:

That's digestion.

482

:

So, uh, you know, is, is a burger,

a beef burger, a turkey burger, or a

483

:

veggie burger better for your body?

484

:

It is going to depend on what r-

what the body receives, right?

485

:

How it's able to break it down, move

it, and deliver it to those locations.

486

:

So instead of some, like, arbitrary

pyramid, it's really gonna be

487

:

about how's my digestion working?

488

:

And so that's…

489

:

Like, literally that's for everyone.

490

:

And one of the things…

491

:

So this book is part storytelling, and,

like, chapter two is Shit to Unlearn.

492

:

It's like this is the stuff that's,

like, not helping us, right?

493

:

So you go through that, and then the

second part of the book is not meant to be

494

:

read, like, cover to cover on that part.

495

:

It's a playbook.

496

:

It's like, okay, I want you to

ask these questions, and if this

497

:

is what's going on for you, this

is what I want you to focus on.

498

:

And I lay it out like a pizza, and I'm

like, the pizza crust, the first thing

499

:

we have to do is digestion and hydration.

500

:

And so in there I'll have you

answer questions, like, when

501

:

you drink water, do you pee?

502

:

When you drink water, do you pee?

503

:

If the answer is yes, you are taking

water in, you are losing that water.

504

:

You are a hose, not a sponge.

505

:

That means that water isn't getting

where it's supposed to go in the body

506

:

in optimal amounts, and when the body

doesn't have what it needs of that

507

:

water in those different locations,

metabolic slowdown, elimination

508

:

of toxins, fat buildup will occur.

509

:

Like, all of these things that we

don't want to have happen will occur.

510

:

So we have to work there first, you know?

511

:

So that's the, the right

order of things to do.

512

:

So now I have to ask- Yeah

513

:

… Speaker: yeah, because I drink

a lot of water- Yeah … and

514

:

I go to the bathroom a lot.

515

:

So-

516

:

Speaker 2: Yes

517

:

… Speaker: how do I, how do

I keep that water in me?

518

:

Speaker 2: Yeah, so that's a great point.

519

:

So we've sold hydration as

this idea of how many ounces of

520

:

water should you drink, right?

521

:

Like, half your body weight, or a

lot of us if you're older, it was

522

:

eight eight-ounce glasses, remember?

523

:

I remember, like, it being

lined up for you, make sure you

524

:

get your glasses in the day.

525

:

And now we all have these, like, massive

mu- like, like jugs- Yeah … that we're,

526

:

like, sipping on throughout the day.

527

:

Okay.

528

:

We…

529

:

Water intake is one component, so you

do need to drink water, but you have

530

:

things that are hydrators, and you

also have things that are dehydrators.

531

:

Dehydrators include str- get ready for

this list, stress, medications, alcohol,

532

:

coffee, sugar, and acid formers, things

like meat and dairy and other things.

533

:

Okay, you don't have to get rid

of those, so I wanna stop before

534

:

somebody hangs up on the podcast.

535

:

Yeah.

536

:

But we have to understand that when we

consume those, those are in, in dif- for

537

:

different reasons and in different ways,

they fall under my class of dehydrators.

538

:

All right, so we have hydrators.

539

:

Our electrolytes, as an

example, are hydrators.

540

:

Not an electrolyte supplement, but the

electrolytes in our body, so potassium,

541

:

magnesium, calcium, sodium, chloride.

542

:

So what we need is that network of

minerals to be in a better balance

543

:

from our food intake and for how

we're, how, you know, maybe our

544

:

supplements in terms of total nutrition.

545

:

And we also need to understand, I'd

said in the dehydrator, how medications

546

:

might be, you know, impacting that.

547

:

Right.

548

:

So our job for hydration actually becomes

assessing these things and optimizing it.

549

:

If you're hearing all of this right now

and you're like, "Oh man, my to-do list

550

:

just went from four things to 400, and I

kinda wanna hang up and forget that I ever

551

:

heard what Ashley is saying," I feel you.

552

:

'Cause some days, like, I feel that way.

553

:

Here's the thing.

554

:

This is why this, the work

of weight health doesn't

555

:

belong with a doctor's visit.

556

:

This is why I'm training, you know,

networks of backwards doctors, registered

557

:

dieticians all around the country.

558

:

This is why we exist, CNSs, certified

nutrition specialists, um, health coaches,

559

:

people who are trained in doing this.

560

:

Um, and you can use things like AI,

you can use my book, you can use

561

:

these other pieces, but the core thing

for you to understand is your body

562

:

is already giving you the signals

of what is not working better.

563

:

We have to decode the right signals and

ditch the wrong signals, and that is a

564

:

process of not listening to the product

pitches on social media, the research

565

:

headlines that pop up on the media or that

people are talking about, and not even

566

:

leaving your doctor's office when they

say, like, "Hey, you know, you, you're,

567

:

um, you know, you've got bone loss.

568

:

I think you should take calcium."

569

:

You're like, "Hold on a second.

570

:

I'm a little smarter than that.

571

:

Calcium may be one factor, but

I wanna look at all of this.

572

:

Let me go back to Your Best

Shot, the book, or let me, you

573

:

know, connect with Ashley's team

or whatever and let me unpack.

574

:

Thank you for giving me the

information about my bone health,

575

:

but let me unpack how, and work with

somebody on how to optimize it."

576

:

Mm-hmm.

577

:

So that, that's what

we've gotta do better.

578

:

Speaker: All

579

:

Speaker 2: right.

580

:

Yeah.

581

:

Speaker: All right.

582

:

And I see the time is moving,

and I'm like- Oh, I know.

583

:

Yes … oh, I could talk to you forever,

but I have two, two questions- Super

584

:

Speaker 2: important.

585

:

Okay

586

:

… Speaker: that, yeah, that I wanna

ask Okay, so what about y- I've got

587

:

these friends, and they, and they

start taking it, and it's like magic.

588

:

Yeah.

589

:

And they're like, they're

like, "The food noise stopped."

590

:

Speaker 2: Yeah.

591

:

Speaker: Yeah.

592

:

I wanna stop the food noise-

593

:

Speaker 2: Yes.

594

:

Perfect

595

:

… Speaker: but I don't really

wanna go on the medication.

596

:

Speaker 2: Okay, so there's two things.

597

:

Speaker: And I don't…

598

:

Okay.

599

:

Speaker 2: Two things that you,

three things that you can do.

600

:

One is you can optimize your own

hormones and see if through that

601

:

process we reduce food noise.

602

:

I wanna be clear, the noise in

our brain is not just about food.

603

:

The noise in our brain is that we exist

in this environment where literally 24

604

:

hours a day things are coming at us.

605

:

So there are things that behaviorally

and from, like, the timing of when

606

:

we eat and, and actually making

our food delicious to us that help

607

:

trigger these hormones to be released.

608

:

There are things that we can do, right?

609

:

So we can do that, and that can work.

610

:

The other one is there is, and I

talk about this in the book, there

611

:

are some supplements, and there's

only one to date in the US that

612

:

actually works as a GLP-1 activator.

613

:

It's from New Zealand,

and it's research…

614

:

Actually, there's a new

study that just came out.

615

:

They, that showed similar to the

medication, so the medication showed

616

:

13 pounds of weight loss, um, where

10 of those pounds were muscle, sorry,

617

:

were fat loss and three were muscle.

618

:

Um, for them, they showed 10

pounds, and it was just fat

619

:

loss, and it was the same window.

620

:

Um, and it was perimenopausal women

and also a calming of the food noise.

621

:

So what the medic- uh, what the

supplement does is the supplement

622

:

actually takes your own hormones to

about 600, like 400 to 600% increase.

623

:

The medications are in the thousands

and thousands of times increase, okay?

624

:

So it's a different world.

625

:

They are not functioning the same way, and

you have to take this, the, the supplement

626

:

works f- for about four or maybe about

eight hours in the day, depending on

627

:

if you're taking it once or twice.

628

:

So that might be an approach.

629

:

And so th- like, in the book I share

with you, there's a continuum on here.

630

:

The most important thing, Lisa, is

that we have to decode what, why is

631

:

the food noise happening for you?

632

:

Mm-hmm.

633

:

My guess is it's a

combination of three things.

634

:

Your gut health, which is always

impacted by hormones changing,

635

:

our environment, other pieces.

636

:

So we optimize gut health.

637

:

Then we come in and we look at, how are

my food choices contributing to or setting

638

:

me up for challenges with food noise?

639

:

One of those is a quick test

that I give you in the book.

640

:

If your food is not delicious enough

to you in the moment- Right … you

641

:

don't get satiety experience, right?

642

:

You w- you have to wait

for fullness to happen.

643

:

So that's gonna be a key thing.

644

:

And then the third one is, depending

on genetics, environment, all

645

:

this other stuff, you might need

a little bit of an activation.

646

:

You might need a little bit of a

boost, and we could look at that part.

647

:

Speaker: Yeah.

648

:

Right.

649

:

What, what is that supplement?

650

:

Speaker 2: Sure.

651

:

It's called Amarolate.

652

:

It's a type of, um…

653

:

It's a type of New Zealand hops.

654

:

It's an extract r- extract from there,

and the branded name is Calocurb.

655

:

Um, and if people want access to

it or access to it at a discount,

656

:

you'll, you'll share the link, um, you

know, my link- Yeah … on that part.

657

:

Um, and you know, I actually

thought it was, um, hogwash.

658

:

When I first saw it I was

like, "Oh, I can't wait for

659

:

the FDA to take this one down."

660

:

And then I, I used it myself.

661

:

I actually had to stop using it when I was

training for an endurance event because

662

:

I was not hungry enough for, especially

for carbohydrates to fuel my workout.

663

:

So it was really interesting on that part.

664

:

Um, so it works great for some people.

665

:

For other people it's not the

better tool, so it just depends

666

:

on what we're working on.

667

:

Okay.

668

:

But food noise, great.

669

:

Speaker: That's so amazing.

670

:

Speaker 2: Yeah.

671

:

Speaker: I love that.

672

:

I love that.

673

:

I'm gonna try it.

674

:

Yeah.

675

:

Um, okay, and then here, I just have

to ask this for a friend, a friend

676

:

who really could use losing weight.

677

:

Speaker 2: Yeah.

678

:

Speaker: And, um, she's tried GLP-1s Two

different kinds, low doses, and so sick-

679

:

Speaker 2: Yeah

680

:

… Speaker: she just can't do it.

681

:

Speaker 2: Okay.

682

:

Like, I'm bringing this to her.

683

:

So let's unpack this one.

684

:

Okay, first of all, and you're

new to this, so I'm g- this is,

685

:

this is what we're working on.

686

:

First of all, no one

can use losing weight.

687

:

No one should lose weight.

688

:

Okay.

689

:

Weight loss is an umbrella under

which we have fat loss, muscle

690

:

loss, bone loss, hair loss, energy

loss, and a loss of our resources.

691

:

All of those, like, only one is what

you're looking for, fat loss on that.

692

:

Speaker: Weight health.

693

:

Speaker 2: Weight health.

694

:

Speaker: I get

695

:

Speaker 2: it.

696

:

Weight health.

697

:

So this is someone who would really…

698

:

Like, where we're saying, like,, "Hey, I

have excess fat," and that is t- that's

699

:

a signal that my body isn't working well.

700

:

Speaker: Yes.

701

:

Speaker 2: So more likely, like…

702

:

And I, I don't have a crystal

ball, and this is not for anyone…

703

:

Like, I'm not anybody's practitioner

here, so please don't go do anything-

704

:

Right … other than work to, you

know, connect with me to figure out

705

:

how we can decode this on your end.

706

:

I…

707

:

So I'm who everybody comes

to when, quote-unquote, "the

708

:

medications don't work for you."

709

:

Like, the 5% are like, that's,

that's where they're coming to me.

710

:

And because I've been doing this

since:

711

:

at every pace of the medications

c- you know, becoming available.

712

:

So the key thing in there is, um, very

likely underlying digestive health or

713

:

some other component was it has not been

addressed and optimized, and as a result,

714

:

the second that this medication was going

into their system, the medication is

715

:

going in, even at the lowest dose, and is

contributing to a worsening of something.

716

:

So it's exacerbating something

that's going on, right?

717

:

Um, so it'd be the same example as if

you were, like- completely exhausted.

718

:

Let's take a new mom who is,

like, up all night, you know, and

719

:

e- and everything else, right?

720

:

And then somebody's like, "Oh, I

think you should go to the gym, and

721

:

I think you should strength train."

722

:

And by the way, this happens all the time,

and I'm like, "Oh my God, please give them

723

:

the middle finger," like, on behalf of me.

724

:

Like, new moms- … you

need rest and recovery.

725

:

Like, we do not need to, like, add,

you know, something to your to-do list.

726

:

So she's, like, in the gym, and

it's like, "I'm falling apart.

727

:

I'm not making muscle, and in fact

I'm, like, gaining fat," whatever.

728

:

And her body's like, "Stop."

729

:

Like, you just birthed a being.

730

:

Like, recovery.

731

:

So in that space for

this person, the, the…

732

:

what was going on in there, something,

it needs to be addressed first, and

733

:

then we can determine do we use this

tool or do we not use this tool, right?

734

:

Mm-hmm.

735

:

So one of the reasons I share the,

the GLP-1 shot or not, yes, it was

736

:

a marketing play on, on my book

cover 'cause I want people to know

737

:

you can do either forever, you know?

738

:

But the other thing is I tell all the

stories in my book of people who did not

739

:

use this, whether it's when it wasn't

available, um, and they've been super

740

:

successful, or whether now that it's

available it just wasn't what they wanted.

741

:

And my job, in addition to things

like CaloCurve, is to help somebody

742

:

understand that, you know, if your gut

doesn't have the right types of bacteria,

743

:

Akkermansia muciniphila, Bifidobacteria.

744

:

If we don't have the right polyphenols,

if we're not making short chain

745

:

fatty acids, if our fibers…

746

:

If we're not getting in fibers, if we're

just, like, freebasing psyllium and

747

:

taking it as a supplement but we're not

getting all these other ones, right?

748

:

We're not going to actually be

nourishing our own hormones.

749

:

And so by not nourishing our own

hormones, or if we're on a medication

750

:

that is additionally, you know, impacting

our gut, we're never gonna net, net

751

:

out in a favorable space because of

the way that these medications work.

752

:

So when you have side effects, there's,

like, two types you wanna understand, and

753

:

especially for your, your friend here.

754

:

You wanna understand that there are some

side effects that could happen to people

755

:

based on what's already going on in their

body or how they use the medication.

756

:

And then there are, like, the direct

effects of the medication working, and

757

:

that's where what we use to determine

whether or not the medication is

758

:

a good fit for you on that piece.

759

:

Speaker: Right.

760

:

Okay.

761

:

Yeah.

762

:

That was so helpful, and I just,

before we go- Yeah … I have

763

:

to say how much I appreciate you

talking about rest and recovery.

764

:

Speaker 2: Ugh.

765

:

Right?

766

:

Speaker: Oh, thank you.

767

:

You just…

768

:

Yeah.

769

:

Because in

770

:

Speaker 2: my

771

:

Speaker: own- Our shoulders

772

:

Speaker 2: both went down.

773

:

I know.

774

:

Like, our shoulders

like another inch, yeah.

775

:

Speaker: And that was the thing, as a

woman, as a professional my entire life.

776

:

Yeah.

777

:

I, I, like, I think I got all the

pieces, and then I went through

778

:

my stage one breast cancer-

779

:

Speaker 2: Yeah

780

:

… Speaker: diagnosis.

781

:

I mean, it was so scary.

782

:

But I think the thing I

was missing was the rest-

783

:

Yeah … and the fun and the joy.

784

:

And, like, if you're going through

something hard like divorce, sometimes

785

:

all you can do is kinda sit and move your

body and feed yourself, you know, try to

786

:

take care of yourself in those moments.

787

:

So this is kind of for when you have

a little time to process and to be

788

:

able to really take care of yourself.

789

:

But I love that you brought up

recovery, because it's the thing

790

:

that I always missed, and I think-

791

:

Speaker 2: Yeah,

792

:

Speaker: yeah … many women,

especially my age, miss it.

793

:

Speaker 2: Yeah.

794

:

Yeah, you know, I'm, I'm, like, kind

of against all wellness trends, 'cause

795

:

I just see this wellness industry

that's making a ton of money, and,

796

:

like, we're more and more and more

unwell in a variety of different ways.

797

:

Speaker: Yeah.

798

:

Speaker 2: And one of the key ones

in there i- right now is this whole

799

:

attention to strength training.

800

:

Like, every woman, everybody

needs to strength train.

801

:

And I'm like, "Dude, if your day,

dudette, whatever- … if your day,

802

:

right, ladies- Yeah … if your day

is challenging your muscles, then

803

:

my, what's on your to-do list is

allowing your muscles to relax, right?

804

:

Speaker: Yeah.

805

:

Speaker 2: It's like we just, you

know, w- we have to look at the body

806

:

as this operating system and being

like, you know, the, the version of

807

:

human doing as opposed to the version

of human being, like, we just, we're,

808

:

we're like a lot of yin versus yang.

809

:

Like, you know, we're just mis- oftentimes

we're too far on one side of things.

810

:

Mm-hmm.

811

:

And I think one of the beauties, like,

so I always, I, I've had a lot of,

812

:

like, necessary endings in my life.

813

:

So that's what I look, you know, with,

with divorce, like, I think, you know,

814

:

as, as we're here in this space- The

beauty of those is that if we give

815

:

ourselves the time to, to rest and

recover instead of just diving into

816

:

doing, we actually see and our body

experiences and we become the version

817

:

of ourselves that we actually want to do

to move into the next phase of our life.

818

:

And that brings in, whether, whether

you ever have another partner or

819

:

not, like, your choice, but…

820

:

Or however life will unfold, but

it will bring into your life what,

821

:

what it is you're meant to be doing

and, and who's supposed to be in it.

822

:

So, you know, when I wrote Your

Best Shot, I'm a total marketer,

823

:

people were like, "Oh, the shot."

824

:

Like, it's 'cause you're

talking about, you know, GLP-1s.

825

:

I was like, "No, I'm talking about

I want you to have your best shot

826

:

at fulfilling your life purpose."

827

:

Like, this is big up there for me.

828

:

Yeah.

829

:

If my eight-year-old self had stayed

dieting for my whole life, I never

830

:

would've become Ashley Koff, RD, and this

is exactly what I'm supposed to be doing.

831

:

And someone out there who's going through

divorce, who feels badly about their

832

:

body or whose body is feeling badly

about itself and it's showing them,

833

:

is so challenged by that, that they're

not gonna solve uterine cancer, right?

834

:

Right.

835

:

And they're that person,

and we need them, right?

836

:

Yeah.

837

:

So that's, you know, I think that's why

we're here, and that's why I do this.

838

:

Yes.

839

:

Speaker: I love it, and that's

the perfect spot to end.

840

:

Great.

841

:

And I'm picking up your book.

842

:

I'm- Thank you … right after this.

843

:

Thank you.

844

:

And it's going to be in the show

notes, so listeners grab it.

845

:

I know I'm gonna be talking about it more.

846

:

This was so impactful.

847

:

Thank you.

848

:

So helpful.

849

:

You're just a joy.

850

:

Thank you for being here, and thank

you for doing the work you're doing.

851

:

Speaker 2: Thank you for

doing the work you're doing.

852

:

You're helping so many,

so I appreciate it.

853

:

Speaker: Oh, thank you.

854

:

Take good care.

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About the Podcast

Doing Divorce Different with Lesa Koski
Divorce, co-parenting & midlife comebacks for women over 40
Divorce, co-parenting, menopause, marriage, and starting over after 40—this podcast is your guide to a healthier, faith-filled life transition.

Hosted by family law attorney, mediator, and life coach Lesa Koski, each episode is designed to take the fear out of major life change and guide you toward peace—whether you’re facing separation, navigating a divorce, working to strengthen your relationship, or rebuilding your life in midlife.

You’ll get heart-centered legal clarity, emotional support, and practical tools to help you heal, grow, and move forward with confidence.

Topics include:

Peaceful divorce strategies and mediation support

Co-parenting help and parenting plans that actually work

Prenups, postnups, and how to protect what matters most

Emotional healing, mindset shifts, and confidence after a hard season

Menopause, health changes, and how midlife affects mood, marriage, and motivation

Wellness basics that make a real difference: rest, nutrition, movement, strength, and community

This is more than a show about endings—it’s about becoming the woman who rises stronger, steadier, and clearer on the other side.

About the Host:
Lesa has spent over 25 years helping families through mediation and family law, always focused on protecting what matters most—your kids and your peace of mind. She’s also a breast cancer survivor, wellness advocate, cowgirl at heart, and follower of Jesus who believes your hardest season can become your greatest comeback.

If you’re craving practical guidance, soul-level encouragement, and real conversations about rebuilding life after 40, you’re in the right place.

Website: https://www.lesakoski.com/

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Lesa Koski