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Published on:

28th Oct 2025

Hormones, Metabolism & Midlife Health: How to Thrive Naturally with Functional Medicine Expert Marrie Simpson

Hormone imbalance, weight gain, brain fog, and burnout after 40? You’re not alone. In this episode of Doing Life Different, Lesa Koski welcomes functional medicine practitioner Marrie Simpson for an open, empowering conversation about hormones, metabolic health, and how women can take back control of their well-being—naturally and holistically.

Marrie shares her personal journey from prescription-based medicine to root-cause healing, and dives into actionable steps women can take to balance hormones, increase energy, improve sleep, and support metabolic fitness—especially during perimenopause and menopause.

If you're feeling stuck, overwhelmed, or out of balance, this episode is packed with hope, education, and next steps—without the overwhelm. Whether you're dealing with hot flashes, insomnia, low libido, or just a nagging feeling of "not quite right," you're in the right place.

🎧 Plus: Lesa shares her own experience navigating estrogen blockers after breast cancer—and how Marie's guidance has helped her reclaim her energy and mindset.

⏱️ Timestamps:



  • (00:00) Introduction: Meet Marrie Simpson



  • (03:15) Marrie’s journey from traditional medicine to functional healing



  • (09:42) How hormone imbalance affects women 40+



  • (15:27) Understanding perimenopause and estrogen dominance



  • (19:44) The real impact of cortisol, stress, and sleep



  • (23:16) Weight gain and metabolic slow-down in midlife



  • (30:03) What women can do naturally to support hormone health



  • (34:55) When hormone replacement therapy makes sense—and when it doesn’t



  • (42:48) Alcohol, estrogen, and breast cancer risk



  • (48:19) Why listening to your body is the most powerful strategy



  • (51:30) Final words of hope from Marie and Lesa


✅ Key Takeaways:



  • 88% of chronic illnesses are connected to metabolic dysfunction—not genetics.



  • Cortisol and estrogen dominance are often the hidden culprits behind midlife weight gain and insomnia.



  • Women can take a natural approach to healing through diet, stress management, muscle preservation, and detoxification.



  • Hormone replacement therapy can be powerful—but only when individualized and timed correctly.



  • Alcohol increases breast cancer risk and interferes with hormone balance. (One glass of wine per night may not be as harmless as you think.)


👩‍⚕️ Guest Bio: Marie Simpson, PA-C, IFMCP

Marrie Simpson is a licensed Physician Assistant and certified Functional Medicine Practitioner. Founder of Elevate Health and Wellness, Marrie blends her clinical training with deep compassion, science-backed protocols, and personalized coaching. With specialties in metabolic health, hormone balance, autoimmune conditions, and genetic optimization, Marie empowers women to heal root causes—not just symptoms.




🔗 Resource Links:

DIY Parenting Plan Course


Find More From Lesa Here!


Marrie Simpson’s Metabolic Reset


jjflizanes.com/lesa



🔎 Tags/Keywords:

perimenopause, menopause, hormone imbalance, functional medicine, Marrie Simpson, Lesa Koski, breast cancer recovery, metabolic health, estrogen dominance, cortisol and weight gain, Dutch hormone test, natural hormone support, midlife weight gain, healthy aging women, women’s health podcast, hot flashes natural remedy, hormone replacement therapy, sober curious midlife, hormone health podcast, doing life different podcast, aging gracefully, holistic hormone support

Transcript
Speaker:

Welcome listeners.

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I am always excited to have

my darling friend, my prayer

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warrior Marie Simpson with us.

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She is my functional health

practitioner that I love.

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And you know what was funny?

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I was telling Marie before we got

on, usually when I do this podcast,

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I, I let people tell their authentic

story and I was watching something.

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On Marie, a different video, a side

video, and I'm like, I've never

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had her do that on the podcast

and your story, it helps people.

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It helps people learn.

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You know, when you go through something

difficult and you learn from it and

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you share it, you share that story.

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That's how we encourage

and change the world.

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And so I just wanna take a little

time to get to know Marie better.

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We're gonna do that first, but just so

you know, this episode you are gonna

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love 'cause it's all about hormones.

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We're gonna talk, touch a little bit

on perimenopause and menopause and

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then um, we're gonna talk about what

we can do kind of naturally, right?

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Without hormone replacement meds.

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Then we're gonna delve into how do you

know when it's time or if it's necessary.

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And Marie can help us with all of that.

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And I just wanna add one more thing that

all of this is really hard to talk about.

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I feel like when we don't

talk about metabolic.

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Fitness, metabolic health, and Marie

has taught me so much about that.

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So listeners, I do have another episode,

but what I want you to know is when I

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do my saddle up segment on Thursday, I'm

going to go through what I've learned

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from Marie briefly about metabolic health.

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And if you are interested, I have.

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How to connect with

Marie in my show notes.

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It's even on my website.

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Or you can just, I'll put her

website on in my show notes too.

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So that was a really long introduction,

but Marie, thank you so much for being

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here, for taking the time and welcome,

and let's get to know you a little better.

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What led you to do this

Phenomenal work for people.

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Yeah.

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Speaker 2: Well, thank

you so much for having me.

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I always love.

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Being on your podcast and so appreciate

you and right back at you with all

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those beautiful things you said about

me because you are just a, just a

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sweetheart and a prayer for me as well.

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So, um, so I started in medicine.

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I always love helping people and, and

so I knew that I wanted to go into

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medicine, always interested in it.

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I love, love, love learning, and so.

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I became a physician assistant back in

:

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in a nursing home for years before that

and just always kind of in that area.

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Um, practiced family practice for a

number of years, but I just was like,

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wow, I am putting people on prescriptions.

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I have 10 minute visits.

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We are not getting at the rut, and I

thought there has to be something more.

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I don't wanna just keep

doling out prescriptions.

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And so started in functional medicine.

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It took me a while to get my, um,

certification in functional medicine,

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probably about seven, eight years.

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But I started, started

in hormones actually.

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Uh, and then just kept going

deeper and deeper and deeper

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with autoimmune conditions.

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Uh, I spent some time under Dr.

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Dale Breon, who wrote

the book, the End of.

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Alzheimer's, he's had a couple subsequent

books, but really looking at how

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do we prevent disease and how do we

prevent the need for prescriptions?

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And I use this analogy all the time.

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Bad, better, best, bad, doing nothing.

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Okay?

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So we don't wanna have high

blood pressure and not treat it.

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We don't wanna have high

blood sugar and not treat it.

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We want to understand what we have

and if we can prevent the need for

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medication, that's gonna be best.

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But better is gonna be

that we use medication.

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So medications are indicated.

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Uh, and we definitely feel, I feel that

traditional medicine has its place, but.

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It doesn't do the best job at disease

prevention at increasing our health span.

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So I started in functional medicine,

uh, and I wasn't the healthiest, but

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I started implementing many, many

things I've been overweight for since,

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since actually I was a kid and didn't

get to do the things I wanted to be,

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uh, in pom-poms and cheerleading.

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But, you know, my weight really

held me back in a lot of areas.

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So became had difficulty getting pregnant

because of my weight, because of PCOS.

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I had a diagnosis of fibromyalgia.

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I had many, many symptoms.

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Again, the hormone imbalance.

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I had chronic achiness

and pain, I had insomnia.

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The list was long.

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I started addressing all of these things

from a functional medicine approach,

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uh, as I learned functional medicine

and how to do things, but my weight

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would not, my, it was, I just was stuck.

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I had tried hundreds, literally

hundreds of things, whether it

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was, you know, diet and exercise.

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I would maybe eat 500 calories a day

and I would exercise three or four

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hours thinking if I just worked harder.

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Yes.

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Then the weight's gonna come off and.

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And after I started my own practice,

um, I, I left the clinic practice in

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about four and a half years ago and

started Elevate Health and Wellness,

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which is what I work under right now.

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Then I went through a program

myself that was really helpful.

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It didn't have the functional medicine

aspects, but it was helpful for losing

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weight, really training your body on

how to detox, how to, um, optimize.

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Fat burning.

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How to really support the body through

the process because we know that

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toxins are stored in fat, and so as we

are working on burning fat for fuel,

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we are going through detoxification.

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Also, focusing on balancing hormones and

optimizing energy, and really getting at

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the root of so many pieces, looking at gut

health, looking at brain fog, looking at.

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Autoimmune conditions and all of that,

just all bringing lots of pieces into it.

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So I've created my own version of

this with genetics with continuous

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glucose monitors, because these pieces

really help give us understanding of

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what's going on behind the scenes.

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Our body gives us clues whether

you have digestive issues, whether

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you've had a diagnosis of cancer

that is a clue about immune health,

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whether you have, uh, brain fog.

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All these pieces are are clues.

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And so we put that detective hat

on and we think, okay, what's

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going on behind the scenes?

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And then we look at.

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Labs, the continuous glucose

monitors give us information.

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Genetics help me personalize

fine tune what recommendations

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that I would typically have.

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And so over the course of the

last four years, I've continually

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added and developed the 12 week

program for what it is today.

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And it was my personal transformation.

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It was learning all of the pieces

that, uh, can keep people stuck.

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And it isn't a one size

fits all as we know, right.

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So that and a coupled with my dad

and my dad started becoming ill.

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15 years ago and he had diabetes and he

started gaining weight around the middle.

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Um, but then came the tremors, it

came some personality changes, uh,

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frequent falls, and eventually he

was diagnosed with Parkinson's.

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And that really helped me.

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And that's around that time

I was doing the, uh, brain.

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Optimization with Dr.

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Dale Bredesen's training and really

looking into what is going on with my dad

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and come to find out that we know 88% of

all chronic illness comes from a metabolic

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disorder, and he certainly had that.

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He had the weight around the

middle, he had the diabetes, and

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so just kind of working along.

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We have managed to halt progression

for many, many years, and now

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as he's now in his eighties.

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Um, 84 to be exact.

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We've, we've, we've seen continued

progression and he has good days and

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bad days, but he is a hundred percent

rely reliant on other people to care for

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him with eating, with, walking, with,

caring for any, anything that he needs.

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It's based on somebody

else, uh, caring for him.

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So his health span was cut way too short.

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We know the average lifespan is.

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77, uh, and the average health span is 65.

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So it's like, what are we gonna

do with that last 10 to 12 years?

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Uh, and we wanna, we wanna lengthen

lifespan and lengthen health span mm-hmm.

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So that people don't have to suffer.

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Like I see so many people do.

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So, all right.

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Speaker: Too long.

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I know men that, I love that.

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I love learning that about you.

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And that is why you're the

amazing woman that you are.

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Oh, thank you.

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Because you've, thank you.

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You've learned and you share it.

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And, and that's what we need.

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That's what we all need, need to

do, is share the things we learned.

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So I have so many questions popping up.

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One thing I wanted to mention mm-hmm.

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That I've heard you say before is

it's important to know our why.

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So we're sitting here today and.

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As a woman, you know, I know

my why is I wanna feel better.

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Mm-hmm.

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I want to grab my grandchildren, pick

'em up, carry 'em down the street.

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I wanna run, I wanna

play, I wanna feel good.

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Mm-hmm.

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And so, and there is a part of it

that I kind, I wanna look good, but I

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think even more is, I wanna feel good

now at this stage in my life, but.

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Here's the thing that so many

women my age, and I didn't even

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think I was gonna mention this, but

it kind of goes along with this.

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Mm-hmm.

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They're like, oh my gosh,

why I've gained weight.

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Women who have remained at a steady,

great weight all their life, and

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all of a sudden they're like.

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What is going on.

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Mm-hmm.

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Why am I suddenly like I can't

do anything and I've been there.

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Mm-hmm.

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I have been there when I

couldn't really do anything.

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So those, and I wasn't obese and it

wasn't a big deal, but it does me

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being five pounds more than I need

to be affects my blood pressure.

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Mm-hmm.

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Mm-hmm.

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So learning the how to be

metabolically fit changed my life too.

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Mm-hmm.

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And you helped with that.

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So let's talk about that.

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Is that hormone related that

suddenly we wake up and we go.

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Everything that I used to do isn't

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Speaker 2: working.

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Yeah.

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You know, it's, it's, it is

hormones and it's more than that.

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Uh, I feel that the modern conveniences

of life have, have increased that

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propensity for weight gain just because.

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We're in front of screens, we're rushing

around and like you, I have 10 grandkids.

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I have aging parents, I have

three kids, I have a husband.

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I'm running a business,

and things get kinda crazy.

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And so I know it's really important

that we manage that cortisol because

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when cortisol goes up and oftentimes

it's really, you know, we're gonna see

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blood sugar elevation, which is gonna

have influence on metabolic health,

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but that that cortisol elevation will

completely override our sex hormones.

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So that's one piece.

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The other piece is we're not moving

as much, and so we know that muscle

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will deteriorate after the ages of 30.

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We start to lose about

three to 8% of our muscle.

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And it depends on the person, right?

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Um, and so as our muscle goes down,

our metabolic, you know, activity slows

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and we can start to see weight gain.

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Uh, so that's, that's a piece.

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So cortisol elevation.

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Lack of muscle and, and muscle tone,

muscle strength, lack of sleep.

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Mm-hmm.

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So if we're in front of screens and we're

stressed, we often don't sleep as well.

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That has a big impact on.

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A cortisol, but also on our metabolic

health and just our nutrition.

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Yeah, our nutrition is foundational.

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It's a foundational pillar, and so when

we're stressed and tired, we may not feel

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like cooking those veggies and getting.

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Clean healthy meals, right?

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Nutrient dense meals.

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And so those are other pieces.

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When our estrogen starts to decline

and our progesterone, particularly our

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pres progesterone first, then we, we

can have estrogen dominance and that

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also can have a tendency to increase.

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And so there's just all these

little pieces that add, it's,

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it's like a puzzle of Right.

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10, 15 pieces that add to that.

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Speaker: Mm-hmm.

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Well, okay, so let's talk a

little bit, I don't like, I think

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most people kind of know what

perimenopause is and what menopause is.

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Mm-hmm.

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But when you were just

saying that the estrogen.

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Increases.

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Is that per, is that perimenopause

that that happens or more Yeah, so

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Speaker 2: perimenopause, we're gonna

see progesterone start to decline

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first, and when that declines, we have

more incidents of estrogen dominance.

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We see perimenopause in the late thirties

and, and typically in the forties.

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And it's not that hormones are just like.

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Going down, down, down,

it's, we're seeing shifts.

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We're seeing things that are up and down.

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Progesterone is the hormone that we

see decline first, and so we wanna have

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estrogen and progesterone balanced.

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But if we're seeing a decline

in progesterone and estrogen

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staying high, that creates.

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Estrogen dominance, so having too much

estrogen and too little progesterone,

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and that in and of itself can cause

heavier periods, maybe fibroids.

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Mm-hmm.

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Dense breast tissue.

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PMS, those are some of the common.

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Signs of tro, I think I have all

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Speaker: those.

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Yeah.

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Speaker 2: And we can see that

even before perimenopause.

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I see that in a lot of individuals

and we have synthetic estrogens

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that people can get exposed to

that will also compound that.

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Mm-hmm.

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And so we wanna be careful around,

you know, plastics and receipts

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and, and different things like that

are, are personal care products.

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Mm-hmm.

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That can have that influence on the

synthetic estrogens, uh, as well.

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So.

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Speaker: Okay.

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That's good to know.

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I dunno if that

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Speaker 2: answers your question.

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Speaker: No, it does.

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And, and that kind of

talks about perimenopause.

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Mm-hmm.

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Okay.

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So then, and, and when you talk

about like not sleeping as well.

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Mm-hmm.

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So then I went, ding, ding.

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So your hormone then is starting to

affect your stress, your cortisol,

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'cause you're not sleeping as much.

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Mm-hmm.

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So that's playing a role too.

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So, so definitely.

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And

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Speaker 2: progesterone is particularly.

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When we think about progesterone, that

is the hormone that is more calming.

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Yes.

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And it does help to promote good sleep.

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And so in that perimenopausal timeframe,

sometimes we'll use some bioidentical

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hormone, just progesterone before bed

to help people with that sleep and, and

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feel more calm and and type of thing.

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So it can be really helpful.

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I, in

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Speaker: fact, I did do that.

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Mm-hmm.

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And I did not have, uh, hormone cancer.

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So that is not what led, but I did do

that, and I do remember the relief I felt.

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Mm-hmm.

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Um, and I was able to sleep.

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And then la la, la la la time

moved on and menopause kicks in.

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Mm-hmm.

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So tell us just really quick

what that is and then things kind

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Speaker 2: of changed again for me.

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Right.

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So we define menopause as not

having a period for 12 months.

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And that's when it's kind

of typically menopause.

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And that can be rarely in

the thirties, but typically

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late forties and and fifties.

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So the average age is about 51.

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And, and with that, the estrogen

starts to decline and sometimes

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it's gonna bounce around.

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So when women go into the clinic and

they say, I wanna have my hormones

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checked, we could look at estradiol.

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Uh, but it isn't as accurate unless

we're doing a specific test where

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we're testing at a particular, um.

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Time of the month unless

you're postmenopausal.

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And so there's the main hormone that

they look at is what's called FSH.

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If we're going to be doing a

test to assess menopause in

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women that haven't had a period.

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Um, so.

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During post menopause, then we see very

little, a little bit, but very little

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estrogen and progesterone production.

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Mm-hmm.

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And then those symptoms typically are

gonna be night sweats, hot flashes,

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vaginal dryness, lower libido,

and we can see some of these in

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that perimenopausal time For sure.

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Um.

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Sleep changes, energy changes, uh, we can

start to see a decline in bone density.

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Mm-hmm.

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Uh, after, after the hormones, after a

period hasn't been present for a year,

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that's when typically they're gonna

recommend that women have a bone density.

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Um, just to assess kind of where

things are at, see some hair changes.

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Um, so those, those would

be symptoms of menopause.

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Speaker: Okay, so now what I wanna do is

I wanna talk about, and I think we've kind

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of covered it, but what are things that we

can do to ha help our hormones naturally?

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Mm-hmm.

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Mm-hmm.

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And then I wanna talk about.

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Because it is a trick to

figure out your hormone levels.

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Yeah.

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And how do you know?

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And there's all kinds of, I think there's

controversy about is it good, is it bad?

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And I think you really wanna catch where

you're at with those and it fluctuates.

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Mm-hmm.

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So I wanna get into that a little bit too.

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So what can we do, because

I can't take hormone.

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Mm-hmm.

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You know, and I am on an oxygen

blocker since breast cancer.

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Mm-hmm.

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And I know, you know, one in eight women

might be going through what I'm going

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through, who are listening to this.

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Mm-hmm.

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But I just have to ask too, a

little bit for my own wellbeing.

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Mm-hmm.

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What can

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Speaker 2: I do?

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Yeah, sure.

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Well, these are great questions

and so I'm gonna kind of try

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to answer each one of those.

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Natural ways, and that's one of the

things that I work on with women

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in the program that I have, and

it is helping to balance hormones.

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And so nutrition is really important.

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We want to, and, and for you too, Lisa,

not being able to use hormones, but being

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able to really optimize health stress

is gonna be a huge thing to manage, but

361

:

then nutrition, bringing in cruciferous

vegetables is going to be helpful.

362

:

Whether you're on hormones or not,

genetics is gonna give us a clue

363

:

about how we metabolize estrogen.

364

:

Uh, and then you mentioned some testing.

365

:

I recommend Dutch hormone testing

because we're gonna look at, you

366

:

know, a, where those hormone levels

are, but then also and, and also

367

:

cortisol 'cause that is gonna have

an influence on our sex hormones.

368

:

The other piece that it looks at is.

369

:

Metabolites.

370

:

And when we have estrogen, whether

it's in our being made by our our

371

:

ovaries, or we're using a bioidentical

form of estradiol, then we wanna

372

:

make sure that it's safe, right?

373

:

Speaker: Mm-hmm.

374

:

Speaker 2: Again, whether it's our

body producing it or it is, um.

375

:

It is being given.

376

:

And so we can look to see how

your body is metabolizing it,

377

:

genetics influence that from the

standpoint of detox and methylation.

378

:

I know we're, I don't wanna get

too sciencey, but we wanna look to

379

:

make sure that it's going down the

right pathway and not producing

380

:

metabolites that would increase risk.

381

:

For in men it would be prostate

cancer and in women breast cancer.

382

:

Right.

383

:

Or potentially ovarian.

384

:

And so if people are gonna consider using.

385

:

Hormone replacement therapy, it's

ideal to use that in the first 10.

386

:

10.

387

:

Within the first 10 years, it's gonna

have a much more impact on brain health,

388

:

cardiovascular health, bone health.

389

:

Just overall, when we start it later than

that, it doesn't have as much benefit.

390

:

Okay.

391

:

But the, but the key is we want to

look at each woman individually.

392

:

Mm-hmm.

393

:

And see what their risk factors are.

394

:

What is their metabolic health like?

395

:

Because we know that if.

396

:

Metabolic health is not good.

397

:

We increase risk for cancers, not

just breast, but other cancers.

398

:

Right?

399

:

We wanna look at genetic pieces

to see, are you methylating?

400

:

Well, what are your detox pathways?

401

:

Right?

402

:

And we wanna look at history.

403

:

Do you have that history of

estrogen dominance where you

404

:

had dense breast tissue, you had

fibroids, you had heavy periods.

405

:

You had PMS.

406

:

Mm-hmm.

407

:

All of these other pieces, because if you

have that in your history, it can give

408

:

us clues about what risks you may have.

409

:

In using bioidentical hormone therapy.

410

:

So we wanna take each individual and,

and kinda look at all of these pieces

411

:

answering the thing that we can do

from what can we do from a natural

412

:

standpoint, it is gonna be Whole Foods.

413

:

Healthy fats, adequate protein, getting

in movement, managing cortisol, managing

414

:

stress, um, and we know that alcohol

will raise aromatase and that then

415

:

can increase risk of breast cancer.

416

:

And so if women are using, you know, more

than maybe a glass of wine a week, it's,

417

:

we wanna be very cautious with that.

418

:

Uh, and then.

419

:

Also if women are going to use hormones,

and I do bioidentical hormone therapy

420

:

myself, uh, I test, you know, we

get tests done, but then also I use

421

:

some products that are gonna really

help with that methylation piece.

422

:

So there's a couple

supplements to bring in.

423

:

And even in individuals that

aren't using hormones, if there

424

:

are symptoms of estrogen dominance,

then they can be very helpful.

425

:

So, right.

426

:

I, I, I think I kept going,

427

:

Speaker: no, I love that.

428

:

And this is what I wanna jump in and say.

429

:

Yeah, because.

430

:

I know that if I were sitting

here listening who I am,

431

:

I would wanna know more.

432

:

I would wanna get this done.

433

:

I wanna get it.

434

:

I would wanna, I would wanna

figure this out, and this is what

435

:

I want the listeners to know.

436

:

Mm-hmm.

437

:

Marie is here for you.

438

:

Yeah.

439

:

So connect with her because.

440

:

That is how you're going to have

someone who can scientifically look

441

:

at your body, and I've done it.

442

:

Look at your gene, look at is this

safe for you to use this hormone?

443

:

Would it be beneficial?

444

:

Mm-hmm.

445

:

And I kinda like hearing,

I think I'm almost 10 years

446

:

out of, you know what I mean?

447

:

So maybe, and I did do a little

bit of hormone therapy, so maybe

448

:

I did it at really the right time

and that was all that I needed.

449

:

Mm-hmm.

450

:

Mm-hmm.

451

:

But that's what, I don't want this

because we're throwing out a lot of tests.

452

:

And things, what I want you to know is

Marie can lead you and she's led me to

453

:

which test works and, and she can learn

about it and then you so beautifully

454

:

will share what supplements work.

455

:

You give us, you know, links to

a great place to get them where

456

:

we maybe save a little bit of

money on a high quality product.

457

:

So this doesn't have to sound

overwhelming or scary, right?

458

:

It is for you to just

investigate, do it for yourself.

459

:

Because in order for you to be there

for all the other people in your

460

:

world, you gotta take care of yourself.

461

:

Mm-hmm.

462

:

And Marie, I think what's so interesting

is I did all of this except there were.

463

:

Two pieces in my journey that I

was missing and one was, thank you

464

:

for talking about wine, because

I had my breast surgeon on who

465

:

has a private breast center.

466

:

Mm-hmm.

467

:

She said, wine, alcohol

causes breast cancer.

468

:

Mm-hmm.

469

:

And she actually said, Marie, that the

surgeon general before the one we have

470

:

now, wanted to put that on every alcohol.

471

:

Mm-hmm.

472

:

Bottle so that women who just like

cigarettes say, this causes lung cancer,

473

:

and for some reason it didn't happen.

474

:

That's a big deal.

475

:

And do you know?

476

:

Mm-hmm.

477

:

I grew up in the era of.

478

:

I'd be stressed out all day, you know,

working with the kids and then I'd

479

:

take my glass of wine to calm down.

480

:

That was the wor.

481

:

And I, like almost every night

would have a glass of wine.

482

:

I wasn't a drunk, but that wasn't

healthy and I didn't feel good.

483

:

Yeah, I didn't feel good.

484

:

But every night I'd do it again

because I was like, oh, I'm, you

485

:

feel good for maybe 20, 30 minutes.

486

:

Yes.

487

:

So the piece, so I was, and I think I was

maybe white knuckling it a little bit.

488

:

Well, I better fast this long.

489

:

I gotta work out this hard.

490

:

Yes.

491

:

And what I learned.

492

:

I made it through chemo

beautifully because I chilled out.

493

:

Yeah.

494

:

I ate well.

495

:

I went on walks, I lifted at home.

496

:

I didn't kill myself.

497

:

Mm-hmm.

498

:

And I was so, I became so fit.

499

:

So that's like a lesson

that we can all hold onto.

500

:

So I just had to jump in and

say Maur bottle that she's

501

:

Speaker 2: helped me.

502

:

Yeah, no, and that's so true.

503

:

And it, it is hard because I feel that

a lot of our social events are based

504

:

around alcohol and not all, but many are.

505

:

Yes.

506

:

And I feel that it has

become this in, um, society.

507

:

So, and it is something that I, I also.

508

:

Was doing and, and actually the

Lord has said, Hey, you know what?

509

:

This is not what I have

for you and mm-hmm.

510

:

And I recognize that.

511

:

I wasn't getting drunk and what have

you, but just, just being reliant on it.

512

:

Oh man.

513

:

Yeah.

514

:

This has been a stressful day.

515

:

I, I wanna have a glass

of wine when I get home.

516

:

Yeah.

517

:

Or choosing the restaurant I wanna

go to because this is, you know.

518

:

Yeah.

519

:

And it, and I don't wanna

have anything control me.

520

:

And I felt that it was controlling me.

521

:

And so just praying to say,

Lord, take away those desires.

522

:

Yes.

523

:

Uh, and fill those with

desires for things of you.

524

:

And if you want me to step away

from this, I know it can be.

525

:

Uh, not in my own strength.

526

:

And that's, yeah, it was a prayer

for a long time for me, but I do feel

527

:

confident that's what he wanted for me.

528

:

And, and when you mentioned earlier

about the whole why, my, why kids

529

:

and my grandkids, I wanna chase them.

530

:

I wanna run with them.

531

:

I wanna, yeah.

532

:

You know, go skiing with them in the,

in the winter and I want to slide and,

533

:

and whatever, but it's, I want women

to know that their bodies can heal.

534

:

That is my biggest thing.

535

:

Yeah.

536

:

And I want them to know that.

537

:

They were created for purpose and, and it

isn't to be sick and, and to just settle.

538

:

Yes.

539

:

You, and, and it isn't about

medications and supplements.

540

:

Sure.

541

:

They're gonna play a little bit of a

role, but it's about these foundational

542

:

pillars that we can put in place and just

little steps here and there and there

543

:

that we can start that healing process.

544

:

Yeah.

545

:

Um, and so that's my why.

546

:

I want women to know that they

can feel good, that they can heal.

547

:

And with all of that knowledge

out there, I mean, it's just like,

548

:

oh my gosh, everywhere you turn,

it's this, this, this, this, this.

549

:

Mm-hmm.

550

:

Like, there's a lot of confusion,

but when we pause and we listen

551

:

to what the body's telling us

552

:

Speaker: mm-hmm.

553

:

Speaker 2: What's our gut like?

554

:

What's our brain like?

555

:

Yes.

556

:

What's our, you know, all

of these pieces, then we can

557

:

start learning what's going on.

558

:

And that's what functional

medicine is all about, is looking

559

:

at the root rather than Okay.

560

:

Take this, take that.

561

:

Take this.

562

:

Yes.

563

:

So at any rate.

564

:

That's, I love that.

565

:

And

566

:

Speaker: we're all unique, we're all

unique individuals, so every one of us

567

:

is going to need something different.

568

:

Mm-hmm.

569

:

Not like, you know, here you go,

let me give you the same dose.

570

:

I give this, you know, 400

pound man, it's like, what?

571

:

Like my husband and I go, he's

like almost twice my size.

572

:

Mm-hmm.

573

:

I mean, he used to be, now it's probably,

I'm getting a little closer, but No.

574

:

You know, and then we'll get like

a a, a dosage that's the same.

575

:

Of Advil or whatever.

576

:

They tell us to take the same amount.

577

:

I'm like, okay, that's right.

578

:

That's just bananas.

579

:

So I, I love, that's why I love working

with you because it is so individual

580

:

and you're really looking at me and,

and I think, you know, for those of us

581

:

out there, it, that is where it starts.

582

:

Listen to your body.

583

:

Mm-hmm.

584

:

Listen to yourself,

because you're gonna learn.

585

:

You can be a little

detective and learn a lot.

586

:

Mm-hmm.

587

:

Even without the test.

588

:

For sure.

589

:

Yep, for

590

:

Speaker 2: sure.

591

:

That is the number one place to start

is getting a really good history,

592

:

understanding what were your periods

like, even if you are postmenopausal,

593

:

what were they like before?

594

:

Speaker: Right?

595

:

Did

596

:

Speaker 2: women have miscarriages?

597

:

That gives us a clue where?

598

:

Where does your mammogram show

dense fiber glandular tissue?

599

:

That gives us a clue.

600

:

I mean, all of these pieces give us

clues, and then looking at traditional

601

:

labs that your practitioner may order.

602

:

That isn't necessarily where optimal is.

603

:

For instance, we talked a little bit

about metabolic health before We wanna

604

:

see a fasting blood sugar under 84.

605

:

Speaker: Yeah.

606

:

Speaker 2: We, you know, I see so

many times where blood sugars are like

607

:

ninety nine, a hundred and ten and

it's like, well, okay, we'll check

608

:

it again in six months or a year.

609

:

And it's like, we don't wanna wait.

610

:

Again, we know that 88% of

chronic illnesses from metabolic

611

:

health, we wanna nip that in

the butt and get after it soon.

612

:

So, um, knowing what those

normal parameters versus what is

613

:

optimal can be really helpful.

614

:

So, yep.

615

:

Speaker: Okay.

616

:

Now we're almost running outta time.

617

:

Yeah.

618

:

But you have to ask one more little

thing, because you mentioned that

619

:

you use hormone replacement therapy.

620

:

Mm-hmm.

621

:

Speaker 2: Mm-hmm.

622

:

Speaker: So.

623

:

When is it appropriate?

624

:

And I know it, it is like, uh,

dependent on the individual.

625

:

Mm-hmm.

626

:

But when would that be a a, an appropriate

627

:

Speaker 2: mm-hmm.

628

:

Speaker: For someone to get on

bioidenticals or, or mm-hmm.

629

:

Or what have you.

630

:

Speaker 2: I think looking, uh, I think

early on, if we're gonna use hormones

631

:

again, we're gonna have much more

benefit if we start them within 10 years.

632

:

Yeah.

633

:

If women are.

634

:

Having significant, and a lot of

times when I was working in the

635

:

clinic practice, it would be like

night sweats and hot flashes.

636

:

That would be the driver of people

using hormones, and I think that

637

:

it certainly is helpful when I

have women go through the program.

638

:

When we start working together,

we can put together pieces.

639

:

And I already alluded to the,

the nutritional aspects mm-hmm.

640

:

And the, um, alcohol being one.

641

:

Right?

642

:

Yep.

643

:

Uh, which is, can, can be hard for people,

but then also not pushing our bodies.

644

:

And like you said, you know, used to go

to the gym and, and I was working out

645

:

so much and I wasn't seeing benefit.

646

:

I had night sweats.

647

:

Hot flashes when I was still

menstruating because I was

648

:

just pushing myself too much.

649

:

Yeah.

650

:

And that just makes it worse, so, so if

you're having night sweats, hot flashes,

651

:

sometimes people have a lot of brain fog.

652

:

Um,

653

:

I think it's then time to look at.

654

:

Benefits versus risks, right?

655

:

We wanna make sure that the benefits

outweigh the potential risks.

656

:

And what are those risks?

657

:

That's what I ask, right?

658

:

Most of the time, we can get night

sweats and hot flashes to resolve.

659

:

With natural methods.

660

:

And so again, stress.

661

:

Um, sometimes I'll use some

black koosh, sometimes rhubarb,

662

:

so estro vera is rhubarb.

663

:

That can be helpful.

664

:

Uh, but most of it is gonna be

lifestyle and nutritional pieces that

665

:

can, that can really shut down the,

um, night sweats and hot flashes.

666

:

So,

667

:

Speaker: well, and I have to say Marie.

668

:

Mm-hmm.

669

:

When.

670

:

So if I occasionally, like once a

month might have a glass of wine.

671

:

Mm-hmm.

672

:

I get it.

673

:

I start having hot mm-hmm.

674

:

Like hot flashes.

675

:

Yeah.

676

:

I don't ever have them unless, and

that's probably because of that estrogen.

677

:

So, so you're saying like, do everything

naturally that you can Yeah, I think,

678

:

I think that's what you're saying.

679

:

Speaker 2: Well I think, I think

that's, that just makes sense, right?

680

:

Yep.

681

:

To prevent disease.

682

:

Um, no.

683

:

It may be too hard for people.

684

:

And so then we wanna look at if people's

metabolic health, if, if their blood

685

:

sugars are elevated, their insulin levels

are elevated and they're using alcohol,

686

:

I don't think people should use hormones.

687

:

I don't, I don't believe they should.

688

:

And I, I know Naasha Winter, she wrote

the book, metabolic Approach to Cancer.

689

:

Yeah.

690

:

She would say absolutely not.

691

:

Um, and so that's, if we're doing the

right things, then I think that estrogen

692

:

replacement therapy has a place and is.

693

:

Definitely beneficial.

694

:

Mm-hmm.

695

:

Uh, so, and it is gonna be

helpful for bone density.

696

:

It is gonna be helpful for

muscle, it is gonna be helpful

697

:

for cardiovascular health.

698

:

So there is a lot of benefits, um,

to using it in the right individuals.

699

:

If people have strong family

history of breast cancer.

700

:

If we look at genetics and there's

some risks, we can mitigate those

701

:

risks with lifestyle in, in a

couple supplements to make it.

702

:

Yep.

703

:

Safer.

704

:

And so it doesn't shut

the door on it at all.

705

:

Um, E three is a very weak estrogen.

706

:

It, it's estriol.

707

:

And so using a little bit of E three,

um, vaginally oftentimes is acceptable.

708

:

And of course, it, we, I always want

you to talk with your practitioner about

709

:

things, um, but for vaginal health.

710

:

And so that would be something that,

uh, would be certainly an option.

711

:

For

712

:

Speaker: vaginal health.

713

:

Well, I'm gonna even like throw that in.

714

:

Even me, who's on the estrogen

blocker, my oncologist mm-hmm.

715

:

Said that.

716

:

That's right.

717

:

Speaker 2: Yeah.

718

:

Mm-hmm.

719

:

And prescribes it.

720

:

Yeah, sure.

721

:

Yeah.

722

:

Mm-hmm.

723

:

Mm-hmm.

724

:

Yeah.

725

:

So, and it's gonna depend

on, some practitioners are.

726

:

Not aware of the functional medicine,

integrative medicine, you know,

727

:

and some of those types of things.

728

:

And, and there are others that are, that

are practicing traditional medicine.

729

:

So it is helpful to have one

that has some knowledge and

730

:

is trained and it's not that.

731

:

I, I don't like those things that, you

know, they come out what your doctor

732

:

isn't telling you and your doctor's bad.

733

:

It's not that.

734

:

Yeah, no, it's that they're

not, they're not knowledgeable.

735

:

They don't, and they're knowledgeable,

but they just aren't aware of the

736

:

functional medicine pieces and what

we look at and how we want to address

737

:

things early and prevent disease

rather than waiting for it to occur.

738

:

So.

739

:

Yeah.

740

:

Speaker: You know, and I just have

to add before we go, I think that's,

741

:

so that's been so important to me.

742

:

And I feel like God has always led

me to physicians who are open to it.

743

:

Mm-hmm.

744

:

So that I can work with you Marie.

745

:

Mm-hmm.

746

:

And my oncologist.

747

:

Now my oncologist is not an a functional

assessment doctor, and I never would've

748

:

thought I would've gone to the U of M.

749

:

Mm-hmm.

750

:

But when I went there, she, and it's Dr.

751

:

Blaze, if anyone wants to know.

752

:

Yeah.

753

:

When I went to her, she looked at me.

754

:

Mm-hmm.

755

:

And she said, no, you don't need a port.

756

:

You know, there were

different things and Sure.

757

:

Some of the oncologists that I talked to

said, oh, don't cold cap for your hair.

758

:

It won't really work.

759

:

She said, cold cap for sure.

760

:

Mm-hmm.

761

:

And she said, make sure you

use ice on your hands and feet.

762

:

Mm-hmm.

763

:

So I don't have any neuropathy.

764

:

Do you know?

765

:

How rare it is for patients to

hear that from their physician.

766

:

Mm-hmm.

767

:

And so I would just like

to get that word out.

768

:

Like it's not, I'm on

this team or that team.

769

:

We're working together here.

770

:

Right.

771

:

And I feel like Right.

772

:

I have been blessed with those physicians

and I would really like to share that.

773

:

Mm-hmm.

774

:

With more of them share my

story, which we're hoping to do,

775

:

which I'm, I'm moving forward.

776

:

I think you should.

777

:

Yeah, totally.

778

:

Speaker 2: Women can learn so much.

779

:

And it is, you wanna be an

advocate for them, right?

780

:

Yes.

781

:

You've gone through it.

782

:

Yes.

783

:

So, um, yeah.

784

:

Speaker: Yeah.

785

:

I'd love you to hear that.

786

:

And helping those doctors

too understand Right, right.

787

:

How they did things right for

me and how they can do that too.

788

:

So.

789

:

Mm-hmm.

790

:

For all my dear friend, I've

taken up so much of your time.

791

:

I feel like this was so good.

792

:

Yeah.

793

:

And like there was so much information.

794

:

And listeners, I promise I'm gonna do

an overview on my saddle up segment

795

:

and I'm gonna talk about metabolic.

796

:

Health.

797

:

Mm-hmm.

798

:

And just go to Marie.

799

:

If you're ready to delve in and

you're ready to take care of you,

800

:

it's like the great first step.

801

:

So yeah.

802

:

Thank you so much for

being, yeah, thank you.

803

:

Love you.

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About the Podcast

Doing Life Different with Lesa Koski
Real conversations for women over 40 about faith, fitness, and fresh starts
Mindset, movement, and faith after 40—because midlife isn’t a crisis, it’s your comeback.

Welcome to Doing Life Different with Lesa Koski, the podcast for women over 40 who are ready to rewrite the rules, reclaim their joy, and rediscover their purpose. Whether you're navigating divorce, rediscovering your health, deepening your faith, or learning how to have fun again—you’re in the right place.

Host Lesa Koski—wife, mom, coach, and seasoned mediator—brings real talk, relatable wisdom, and expert interviews to guide you through midlife reinvention with grace and grit.

In each episode, you’ll get practical tools and empowering conversations on:

Mindset & personal growth

Faith & spiritual connection

Fitness, movement & health

Divorce, marriage & relationships

Fun, purpose & starting fresh in the second half of life

This isn’t just self-help. It’s soul-level transformation. Get ready to do life different—because your next chapter starts now.

Lesa also explores the emotional and physical changes that often accompany midlife and major life shifts. From navigating the impact of menopause on your health, marriage, and mood, to dealing with the loneliness that can come after divorce or empty nesting, you’ll find honest conversations that don’t shy away from real-life challenges. And for those of you in your 40s, 50s, or beyond, you’ll discover what it means to truly build a better life after 40.

Health and wellness are deeply integrated into this journey. Lesa shares insights on the benefits of rest, joy, nutrition, fasting, protein, and bone health, along with the power of movement, community, and exercise to support mental clarity and physical strength. You’ll learn how to take care of yourself with intention—because healing isn’t just emotional, it’s also biological.

Mindset work and self-coaching are recurring tools offered in episodes to help you reframe your story and shift from fear to freedom. And through it all, the show honors the role of faith, spiritual surrender, and letting God lead you through every season. Whether you're leaning into your relationship with God for the first time or deepening a lifelong practice, you’ll hear how surrender can bring peace even in the hardest moments.

You’ll hear real stories from people who have done divorce differently, saved their marriages, or found new love and purpose on the other side. Lesa also brings in conversations about marriages that have stood the test of time, co-parenting through complex seasons, and the realities of parenting after separation while maintaining stability for your kids.

This is a podcast about thriving through Cancer, taking back your life, rewriting your future, and trusting that you’re not starting over, you’re starting better. If you’re craving practical advice, soul-level encouragement, and real conversations about creating a healthy, joyful, purpose-driven life, you’ve found your community.

Subscribe now and join Lesa Koski for weekly episodes that will help you grow stronger in your relationships, your health, and your faith, no matter where you’re starting from.

About the Host:
I’ve spent over 25 years helping families navigate amicable divorce as a lawyer and mediator, always focused on protecting what matters most—your kids and your peace of mind. But my mission has expanded. Today, I support women over 40 not just through endings, but in building stronger relationships—and sometimes even saving their marriages. I’m a breast cancer survivor, a cowgirl at heart, a wellness advocate, and a follower of Jesus. My life and faith fuel my passion for helping women thrive.

About your host

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Lesa Koski