full

full
Published on:

4th Sep 2025

The Truth About Weight Loss Medications: Insights from Functional Practitioner Marie Simpson

Episode Description

Weight loss medications are everywhere—but do they really work, and are they safe? Functional practitioner Marie Simpson shares expert insights, side effects, and natural alternatives.



In this Saddle Up segment of Doing Life Different, I recap my powerful conversation with Marie Simpson, a trusted functional assessment practitioner, about the rise of weight loss medications. We explore whether these drugs are truly necessary, their impact on muscle and bone health, and how lifestyle habits like high-protein nutrition, strength training, and joy-filled living can support lasting results.



Marie provides a functional medicine perspective on weight loss medications—what they do, when they’re helpful, what risks to watch for, and how to combine them with smarter health strategies. Whether you’re considering medication or looking for natural ways to boost weight loss, this episode gives you the clarity you need.




Timestamps


(00:00) Introduction to weight loss medications and functional health


(02:15) What functional practitioners are saying about weight loss drugs


(05:12) Side effects and long-term considerations for patients


(08:40) The importance of muscle, protein, and bone density on these medications


(11:27) Lifestyle habits that mimic medication effects naturally


(14:05) Joy, stress reduction, and hormone balance for sustainable weight loss


(16:20) Final thoughts: better vs. best approaches to lasting health



Key Takeaways




  • Weight loss medications may help some people, but lifestyle changes remain essential.



  • Side effects exist—muscle loss and bone density decline are key concerns.



  • Prioritizing protein (30g per meal) and strength training is crucial whether on medication or not.



  • Stress reduction and joy play a major role in hormone balance and weight management.



  • Medications can be a bridge, but long-term health requires holistic strategies.




Guest Bio


Marie Simpson is a Functional Assessment Practitioner who helps clients uncover root causes of health challenges through a holistic approach. She integrates functional testing, personalized nutrition, and lifestyle strategies to support sustainable health and healing. Marie brings a balanced perspective to weight loss medications, blending science, practicality, and functional medicine wisdom.




Resource Links




  • Learn more about OsteoStrong for bone health: https://osteostrong.me



  • Connect with Lesa Koski: https://lesakoski.com



  • Listen to the full interview with Marie Simpson on Doing Life Different




Tags/Keywords


weight loss medications, weight loss drugs, functional medicine, holistic health, sustainable weight loss, protein nutrition, strength training, muscle loss, bone density, Marie Simpson, Lesa Koski, Doing Life Different podcast, Saddle Up segment, midlife weight loss, natural weight loss alternatives








Transcript
Speaker:

Welcome to this week's settle up segment where we take key takeaways from

2

:

Tuesday's episode of Doing Life Different.

3

:

And on Tuesday, I was blessed to have my

good friend and the functional assessment

4

:

practitioner, my practitioner, Marie

Simpson on She was talking about what

5

:

we're all talking about are those.

6

:

Those weight loss medications and I

wanted to get the skinny from Marie.

7

:

I wanted to find out what other

functional assessment practitioners

8

:

and natural paths and, um, folks

are saying about these medications.

9

:

I wanted to find out what they do

that we can't do on our own, and

10

:

if there are ways that we can.

11

:

Do things that kind of act like that,

and also just to kind of touch base on

12

:

is it really necessary for somebody who

maybe has five or 10 pounds to lose?

13

:

And so it was a great conversation.

14

:

Go back and listen.

15

:

It's, it's long and detailed and full of,

of good stuff, but I just, I do wanna give

16

:

you just that outlying information so.

17

:

What I learned from Marie is they really

can't find anything wrong with it.

18

:

I mean, you would think there are some

side effects and she talks about those.

19

:

So go back and listen

if you wanna hear those.

20

:

So as with any medication,

right, there can be side effects.

21

:

But other than that, and the fact

that for somebody who's really obese.

22

:

Is thinking about being on the

medication for the rest of their

23

:

lives, you know, and kind of planning

on that might be a good option.

24

:

She also works with patients who are

trying to, working to get off of it.

25

:

The thing that's hard about them, and

the thing that you need to be careful

26

:

of, if you're on, um, some of these, um.

27

:

Medications is that when you

lose the weight, she said, I feel

28

:

like you lose a lot of muscle.

29

:

And so you wanna be cognizant of

your muscle, of your bone density.

30

:

You know, I love osteostrong,

that osteogenic loading and I'll,

31

:

I, you know, we'll talk about

that in an upcoming episode, but

32

:

you wanna make sure that you're.

33

:

If you are on these medications,

you're taking a lot of protein, you're

34

:

doing HIIT workouts and strength

training, kinda what is good for you

35

:

when you're not on the meds, right?

36

:

So I think what she talked about

was how it can really bring hope.

37

:

To people and, and then

they can take the action.

38

:

That's hard to take.

39

:

It's hard to go for a walk

if it hurts when you walk.

40

:

So, you know, take it slow, go on them,

you know, if you need to go on those

41

:

meds, go on 'em and, and do the important

things that you need to do to have a

42

:

healthy lifestyle Along with it, she

always talks about like, um, better.

43

:

And best and like better is doing

it, you know, doing the medication

44

:

best is to also do all the things

like low sugar, high protein.

45

:

Um, so we, we talked a lot about that.

46

:

Um, I asked her about what we can do.

47

:

To kind of replicate what that

medication does because apparently

48

:

it kind of works with your hormones.

49

:

It makes you feel full and satisfied.

50

:

And the things she told me about

protein, and you know, we're hearing

51

:

it, it's, she said, 30 grams per meal.

52

:

I'm telling you, it's kind

of hard to do sometimes.

53

:

She also talked about a way to eat,

and I'm not gonna repeat that here

54

:

because I could mess that up because

I'm not a medical practitioner,

55

:

but she talked about a strategy

on what type of food to eat first.

56

:

Um, but I do know that protein is key.

57

:

Um, we talked a lot about

joy and stress reduction.

58

:

And so, um, you know, I think we tend

to forget that when we're stressed out,

59

:

it makes our hormones go wonky, which

can affect how we metabolize things.

60

:

It can affect, you know,

causing us to eat more.

61

:

And so just as with

everything, we need more joy.

62

:

And even with our eating,

it even plays a factor.

63

:

Our weight loss.

64

:

So go back and listen.

65

:

It's such, I don't know if I'm doing

it justice because I don't have that

66

:

medical background, but the basic

bottom line is she doesn't really have

67

:

a lot of bad things to say about it.

68

:

There are some side effects, as with

any, um, drug, she thinks that yep,

69

:

if you have five pounds to lose,

you can, um, do it, but probably.

70

:

Not necessary.

71

:

And why would you go on a medication?

72

:

Because it's not really gonna benefit

your body like it would someone who

73

:

had a large amount of weight to lose.

74

:

So, um, find the joy.

75

:

Eat your protein, lift your weights.

76

:

Have fun.

77

:

Have fun.

78

:

Go for walks.

79

:

Play tennis, play pickleball.

80

:

Play ping pong For goodness sakes, just do

things to move your body and enjoy life.

81

:

And that seems to be the key to having a

healthy weight and a healthy long life.

82

:

Go back and listen.

83

:

It's a great one.

Listen for free

Show artwork for Doing Life Different with Lesa Koski

About the Podcast

Doing Life Different with Lesa Koski
Real conversations for women over 40 about faith, fitness, and fresh starts
Mindset, movement, and faith after 40—because midlife isn’t a crisis, it’s your comeback.

Welcome to Doing Life Different with Lesa Koski, the podcast for women over 40 who are ready to rewrite the rules, reclaim their joy, and rediscover their purpose. Whether you're navigating divorce, rediscovering your health, deepening your faith, or learning how to have fun again—you’re in the right place.

Host Lesa Koski—wife, mom, coach, and seasoned mediator—brings real talk, relatable wisdom, and expert interviews to guide you through midlife reinvention with grace and grit.

In each episode, you’ll get practical tools and empowering conversations on:

Mindset & personal growth

Faith & spiritual connection

Fitness, movement & health

Divorce, marriage & relationships

Fun, purpose & starting fresh in the second half of life

This isn’t just self-help. It’s soul-level transformation. Get ready to do life different—because your next chapter starts now.

Lesa also explores the emotional and physical changes that often accompany midlife and major life shifts. From navigating the impact of menopause on your health, marriage, and mood, to dealing with the loneliness that can come after divorce or empty nesting, you’ll find honest conversations that don’t shy away from real-life challenges. And for those of you in your 40s, 50s, or beyond, you’ll discover what it means to truly build a better life after 40.

Health and wellness are deeply integrated into this journey. Lesa shares insights on the benefits of rest, joy, nutrition, fasting, protein, and bone health, along with the power of movement, community, and exercise to support mental clarity and physical strength. You’ll learn how to take care of yourself with intention—because healing isn’t just emotional, it’s also biological.

Mindset work and self-coaching are recurring tools offered in episodes to help you reframe your story and shift from fear to freedom. And through it all, the show honors the role of faith, spiritual surrender, and letting God lead you through every season. Whether you're leaning into your relationship with God for the first time or deepening a lifelong practice, you’ll hear how surrender can bring peace even in the hardest moments.

You’ll hear real stories from people who have done divorce differently, saved their marriages, or found new love and purpose on the other side. Lesa also brings in conversations about marriages that have stood the test of time, co-parenting through complex seasons, and the realities of parenting after separation while maintaining stability for your kids.

This is a podcast about thriving through Cancer, taking back your life, rewriting your future, and trusting that you’re not starting over, you’re starting better. If you’re craving practical advice, soul-level encouragement, and real conversations about creating a healthy, joyful, purpose-driven life, you’ve found your community.

Subscribe now and join Lesa Koski for weekly episodes that will help you grow stronger in your relationships, your health, and your faith, no matter where you’re starting from.

About the Host:
I’ve spent over 25 years helping families navigate amicable divorce as a lawyer and mediator, always focused on protecting what matters most—your kids and your peace of mind. But my mission has expanded. Today, I support women over 40 not just through endings, but in building stronger relationships—and sometimes even saving their marriages. I’m a breast cancer survivor, a cowgirl at heart, a wellness advocate, and a follower of Jesus. My life and faith fuel my passion for helping women thrive.

About your host

Profile picture for Lesa Koski

Lesa Koski